Monday, July 14, 2014

Benefits of Femara (Letrozole)

Femara (Letrozole) is a type II (non-steroidal) third generation aromatase inhibitor. Clinically it is used to treat postmenopausal women with either estrogen receptor positive or estrogen receptor unknown breast cancer. In women, tumors that contain estrogen receptors are classified as estrogen receptor-positive (ER+) tumors. For Letrozole to be prescribed, a given tumor must have been diagnosed as estrogen receptor positive or estrogen receptor unknown. In the world of bodybuilding it is used to reduce or eliminate excess estrogen caused by the use of aromatizing steroids.

Letrozole was originally sold under the brand name Femara, and produced by the pharmaceutical house Novartis. It was patented on July 25th, 1997. Letrozole is known  as a type II aromatase inhibitor, meaning, in simplest terms that it attaches to the aromatase enzyme and prevents it from converting androgens to estrogen. In slightly more complex terms, estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme, and letrozole actually inhibits the production of estrogens in by competitive, (reversible) binding to the heme of the relevant cytochrome P450 unit. Letrozole is currently the most powerful aromatase inhibitor available. In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more. However, it’s use and benefits are not limited to eliminating estrogen in women.

In one male test subject Letrozole was able to reduce estrogen levels to undetectable levels, and in another clinical study done on both young and elderly men, intravenous administration of Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. Because estrogen is part of the negative feedback loop of the HPTA, Letrozole (and other anti-estrogens) are able to raise testosterone in male subjects. Letrozole was studied in men, and found to significantly increase LH levels to a 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. Letrozole was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively. In a similar study 0.02 mg of Letrozole increased testosterone by 45% after 2 days. That same twenty micrograms of Letrozole was also enough, in one study done on men, to reduce estrogen levels by roughly a third. Letrozole has a 2-4 day half-life, and it needs to be taken for up to 60 days to get a steady blood plasma level. Letrozole was used in a rodent study to effectively destroy (benign) breast tissue tumors, which may potentially indicate its use in males attempting to remove gynecomastia (aka gyno). As estrogen is also a factor in stopping linear bone growth, Letrozole is currently being examined for potential use in delay of growth seen in children.

In the world of bodybuilding where more is often thought to be better, Letrozole stands almost alone as an exception to that rule. Estrogen is necessary for healthy immune function, healthy cholesterol levels, joint health, cognitive function, and even aids in muscle growth. In my own experience as well as the experience of many bodybuilders and athletes I’ve worked with, Letrozole simply causes estrogen to be reduced to levels too low to function properly. Unfortunately, this compromised my immune system and joint integrity. For most recreational steroid users, Letrozole is going to be too harsh, and cause too many problems. Still, people can use it effectively if they don’t use the manufacturer’s clinical dose (2.5mgs) and instead keep their dose to .25-1mg. There are, however, better choices for an anti-estrogen. I should mention that using Letrozole at such a low dose does happen to make it a very good economic choice compared with other aromatase inhibitors.

For pre-contest bodybuilders, Letrozole is almost a necessity to eliminate water retention and achieve the ripped look necessary to compete in today’s bodybuilding world. However, in my experience, it is only necessary to be used for the last 4-6 weeks, to eliminate excess estrogen and water retention. After using Letrozole I recommend staying away from any estrogen suppression for at least a month to try to normalize the body.

Wednesday, July 9, 2014

Deca Durabolin popular cycle for bodybuilders

If you want to use an anabolic steroid that is effective and affordable besides being safe and free from side effects of steroids and performance enhancing drugs, Deca Durabolin, which is also known as Deca and Nandrolone decanoate, will be an ideal choice for you. Deca Durabolin has an active life of 14-16 days and is detectable over a period of 16-18 months. Belonging to the category of anabolic-androgenic steroids and classified as a 2.16 anabolic steroid, Deca is a highly effective drug that is available in different forms such as creams, pills, capsules, and gels. Medically, the drug is advised to stimulate immune system enhancements and offer dramatic relief to HIV/AIDS patients and even treat specific blood disorders as part of the adjuvant therapy. This steroid is used by sportsmen to benefit from the improved recuperation time between workouts, protein synthesis, and nitrogen retention. Moreover, this steroid is admired as its use even for long anabolic steroid cycles does not result in side effects like oily skin, male pattern baldness, and prostate complications. If that was not all, Deca use is considered of great use to mask minor joint pain and old nagging injuries besides reducing the inflammation of soft tissues and promoting masculine (secondary sexual) characteristics, including growth of the vocal cords, testicles, and body hair. This steroid is commonly used in doses of 300-800 mg per week by men and 50-100 mg per week by women or in doses of 600 mg per week for 12-16 weeks by men for bulking cycles and 400 mg per week for 12-16 weeks by men in cutting cycles.

A popular Deca Durabolin cycle is all about using Dianabol-30 mg every day for week 1-3 and then 40 mg every day for week 4-6 and complementing it with Sustanon 250 mg every week for week 1-12, Clomid 50 mg every week for week 10-12, and Deca Durabolin-200 mg for the first week and then 300 mg per week for 2nd and 3rd weeks, and 400 mg every week for 4th and 5th weeks, and 300 mg every week for the sixth week. Overdosing or use of low grade or abuse of Deca Durabolin can lead to side effects such as may even cause heart attack, edema, prostate enlargement, menstrual problems, liver toxicity, liver damage, and gynecomastia (female-like breasts). It may even cause elevated blood pressure, shrinking of the testicles, bone age advancement, bad effect on cholesterol levels, increased aggression, oily skin, acne, clitoral hypertrophy, infertility, and sexual dysfunction and therefore it is best to use it only after a qualified medical practitioner has authorized its use after evaluating all medical reports and history. Deca Durabolin, which is also known as Deca and Nandrolone decanoate, is one of the best performance enhancing drugs and anabolic steroids when it comes to stimulating endurance and muscle function gains.

The steroid is popular among both amateur and professional sportsmen when it comes to improving the levels of recuperation time between workouts, protein synthesis, and nitrogen retention. The fact that the use of Deca is not related to side effects like oily skin, male pattern baldness, and prostate complications means that it can even be used by those who are prone to these side effects. However, it is best to seek medical advice before making such use and buy Deca Durabolin only from a legal and reputed website. Since this steroid has a very low rate of aromatization that is approximately 20 percent the rate of testosterone, it does not result in estrogenic or androgenic side effects and gives ample opportunities for sportsmen and others to stay high on the sense of well being, lean muscle mass, and unmatched body strength and muscle mass. Deca Durabolin is best used in doses of 600 mg per week for 12-16 weeks by men for bulking cycles and 400 mg per week for 12-16 weeks by men in cutting cycles or in doses of 300-800 mg per week for men (or 2 mg per lb of body weight) and 50-100 mg per week for women. This anabolic steroid is commonly stacked by sportsmen with steroids and performance enhancing drugs such as testosterone cypionate, testosterone suspension, testosterone enanthate, testosterone propionate, Anadrol, Dianabol, and Sustanon 250 and should always be used under medical supervision and for legal purposes as Deca Durabolin abuse can lead to side effects atrophy of the breasts, early epiphyseal closure, hypercalcaemia, hypercalciuria, withdrawal of ovarian action, decreased ejaculatory volume, and more-than-average increase in bone development, suppression of ovarian activity, oedema, and depression. Use of this steroid is not recommended to those suffering prostate cancer, breast cancer, testicular cancer, high blood pressure, stroke, liver damage, kidney damage, jaundice, hepatic carcinoma, or renal failure.

Thursday, July 3, 2014

Injectable Steroids Propionat 100 by Dragon Pharma

Propionat 100- testosterone propionate is a male sexual hormone with pronounced, mainly androgenic action, possessing the biological and therapeutic properties of the natural hormone. In a healthy male organism, androgens are formed by the testes and adrenal cortex. It is normally produced in women in small physiological quantities.
In addition to the specific action that determines the sexual characteristics of the individual, it also has a general anabolic action, manifested in enhancement of protein synthesis. Under the effect of testosterone, body weight increases and urea excretion is reduced. High doses suppress the production of hypophyseal gonadotropin, while low doses stimulate it. It has an anti tumor effect on mammary gland metastases.

The effective dose has a range between 300mg to 2000mg per week for men. For women, the dose is 50mg-100mg per week. Propionat 100 from Dragon Pharma, the injectable steroid that represents the substance testosterone propionate. Propionat 100 is being shipped in its original box containing a 10 ml vial of 100mg/ml, thus it is an original Dragon Pharma product properly marked and labeled. There is also a special bulk offer for it, specially designed for professionals and for those who prefer cycling regularly.

Testosterone Propionate was one of the first anabolic androgenic steroids ever synthesized and made ready for human use in mass production and as such is one of the most popular anabolic steroids of all time. While there are hundreds of anabolic steroids and forms within each, Testosterone-Propionate is largely one of the easiest to understand as it is very basic in composition and simply a pure testosterone. However, as simple as it is it further remains very powerful and highly effective yet many understand Testosterone-Propionate as well as they understand the most basic algorithms used in space exploration.

Testosterone-Propionate like all forms of testosterone is highly anabolic and androgenic, equal in both rights. As by its nature it is simply a synthetic version of the testosterone hormone naturally produced in the human body by both men and women and essential to a properly functioning endocrine system. While inadequate levels, particularly low levels are generally not life threatening they can be quite bothersome and can lead to more serious problems when not dealt with appropriately. To give you an idea of the importance of the hormone we only need look at the effects of low levels; those who suffer from low testosterone find a body transformation in the opposite desired direction to be very common place; increased body-fat, decreased muscle tissue and strength can all occur and be very difficult to deal with and in many cases impossible when levels are too low. Further, because testosterone is responsible in part for sexual function many men find they experience a decrease in libido, erectile dysfunction when levels are too low, as well as lack of mental focus, energy and even the onset of depression. While these are not life threatening conditions on their own, as you can easily see some of them are pretty serious and there isn’t one any man would wish to have bestowed on him. Conversely, when we look at the effects of low testosterone we can easily see how increased levels would have the opposite effect; take each condition previously listed and take it in the opposite direction towards improvement, which is exactly why testosterone is known as a performance enhancer.

By its very nature Testosterone Propionate dramatically increases nitrogen retention in the muscle allowing protein to be stored in the muscle to a larger degree; as protein is the building block of muscle and increased lean tissue improves our metabolic rate, on this basis alone we have a highly desirable hormone; however, the good news does not end there. As by its mode of action testosterone has the ability to block and reduce muscle wasting hormones known as glucocortico steroid, most commonly cortisol. While testosterone truly has seemingly limitless properties, as it pertains to performance, of particular interest is its ability to greatly increase IGF 1 production in the body, as you understand IGF 1 is a very powerful peptide hormone of a highly anabolic nature and plays a key role alongside human growth hormone, another potent peptide based hormone.

Monday, June 16, 2014

Trenbolone Acetate is very effective in cutting and bulking cycles

Estrogenic activity does not occur with this drug in that it has a double carbon bond at position 9 and 10, making aromatization impossible at the A ring and a unique characteristic when compared to Nandrolone. Something else that is unique is that the androgenic ratio is a lot higher than compared to Nandrolone coming in with an anabolic to androgenic ratio of 500/500. Progesterone type side effects is a concern with this drug as both Nandrolone its derivatives possess progesterone-type qualities; you might look at using something like Parlodel or Dostinex on your cycles. Also note while prolactin rises, thyroid levels lower, so it is recommended if you going to be using this compound for a while add T3 to the stack. Please have your blood tests checked before you decide to use these prolactin lowering drugs as you might be adding an extra level of complexity to your cycles by doing so.

Trenbolone side effects include irritated skin at the injection site; hives, oily skin, swelling and itchiness, some users even experience a yellow tinge to their skin. You can also expect to experience increased hair growth, and your sleeping habits disturbed, where you can experience vivid/lucid dreams and night sweats. Some users experience the famous ‘tren cough’ this is actually due to the benzyl alcohol used and your body trying to get rid of it via the lungs which can become extremely dangerous. Increased levels of blood pressure can be expected and in rare cases cardiovascular disease might be a concern. Users also report the inability to do endurance exercises while on Trenbolone so this makes it highly unfavorable for many athletes.

Trenbolone is very effective in both cutting and bulking cycles and just depends on which compound you stack with this powerful steroid. Trenbolone stacks very well with Testosterone and Anavar and/or Primobolan for that extremely hard and dry look. You can also stack Tr

Trenbolone Acetate only has an active life in our bodies of around 3 days, but for stable hormone levels it is advised to pin this drug ED (Every day). The benefit of it being such a fast acting compound is that it gets to work quickly. Trenbolone also comes with an Enanthate ester and has some highlighted characteristics, as you see mentioned above about the Tren Cough, this is not a problem with the Enanthate ester as it is based in oil. The active life of this drug is also prolonged and you are only required to do weekly shots, this is very beneficial when you are looking at doing prolonged cycle duration.

Precision Gear Works offer two versions of this drug, one being Tren 150 which is dosed at 150mg/ml and contains the Enanthate ester and Trenbolone Acetate 80 which is dosed at 80mg/ml of the Trenbolone Acetate ester. Dosage on the acetate ester ranges from around 40mg every day or 80 every other day right up to 80mg every day or 160mg every other day, some users have reported dosages at 200mg ED and, while I think that is just crazy if you compare the anabolic/androgenic ratio to a powerful hormone such as testosterone you will see why. If you are using the Enanthate base you will be looking at around at around 2ml per week, which would be around 300mg of the drug.
enbolone with a Testosterone base and Equipoise to experience some nice quality mass gains. Or you if you are looking for explosive size and strength you can use Trenbolone with a Testosterone base and add Anadrol or Dianabol to the mix.

Monday, June 9, 2014

Dianabol Side Effects

All anabolic androgenic steroids carry with them the likely for negative side effects. The probability largely varies from one steroid to the next and often portion and single response play a massive part; in-fact, single response may indeed be the most important factor. As is with so many things in life some individuals have no negative response no matter how much of a particular item is present, for example, certain foods, while another individual can look at the same food and become sick. The same can be said of most all anabolic androgenic steroids but the good news is for healthy adult men toleration is generally high and side effects are often avoidable or reversible when responsibility is implored. Lets take a look at one of the most popular anabolic steroids of all time Dianabol (Methandrostenolone) and see what we find.

The two most common Dianabol side effects are without question Gynecomastia (male breast enlargement) and excess distilled water retention or bloat. Both of these reactions are due to the hormone aromatizing (converting into estrogen) and as estrogen increases in the corpse these effects can become present-day. For most gynecomastia is avoidable but for quite a few their sensitivity will be so great that nothing short of having their glands removed from their pecs will save them. In most cases a good aromatase inhibitor will prevent Gyno as it is commonly known with Arimidex and Letrozole being our best choices.

As it pertains to water retention, the same estrogenic result is responsible and yet again an aromatase inhibitor will largely reduce and often avert bloat to any serious degree. We must note, as it is a common misunderstanding; many who supplement with Dbol do so when bulking and when they bloat they immediately point to this hormone as the culprit. Absolutely, it may very well play a role but nine times out of ten the primary culprit is the individual eating too much, particularly in the way of carbohydrates. Yes, Dianabol side effects can include water retention but such a side result is so easily controlled that if it does become a difficulty for you then you need to examine other aspects of your plan.

Two other primary Dianabol side effects include high blood pressure and ineffective cholesterol levels. For those who already have high blood pressure this is a steroid you must avoid and if you're predisposed to a high blood pressure condition you are advised to seek alternative steroids without question. Those who have a healthy blood pressure and who do not overdo the portion will generally be excellent; in-reality, its not uncommon to see an athlete supplement with 30mg-50mg of Dianabol a day and never see his blood pressure go up.

The same can be said of cholesterol, your current condition and predisposition will play a great function. Further, if you are healthy and use responsibly youll more than likely be fine. However, it is always best to err on the side of caution and as such it is recommended you ensure your diet is rich in healthy fats, especially those of an Omega Fatty-Acid nature. Such fats have been proven to improve total cholesterol levels greatly and many Dianabol users who have dealt with Dianabol side effects of a cholesterol nature often see their levels improve when omegas are added. Lets not forget Omega Fatty-Acids are simply good for you to begin with and play many significant roles in the muscle game and in our general overall health.