Wednesday, August 20, 2014

Benefits of Trenbolone Acetate

There are numerous forms and types of anabolic androgenic steroids and within each one there are often many variations, testosterone being a prime example of a hormone with many faces. Each and every anabolic steroid can serve a primary purpose and will generally carry with it a few secondary qualities and the degree of each just like the steroids themselves can be quite varied. Of all the steroids we can discuss, from mild to strong, powerful and weak you’d be hard pressed to find a more exciting one than Trenbolone and of the various Trenbolone forms there is none more exciting than Trenbolone Acetate. In-fact, if we were to label any anabolic androgenic steroid the perfect steroid, side-effects aside it would undoubtedly be Trenbolone Acetate.

Like most anabolic steroids Trenbolone’s original intent was not performance enhancement but for the purpose of beefing up livestock and through this desire the hormone was born in the form of Finaplix (Fina) a subcutaneous implant that contained the hormone to be used in cattle.  However, it would not simply be Trenbolone’s raw bulking power that made it so popular but its true versatility, as it would prove to be and still to this day the most versatile anabolic androgenic steroid on the market. Most anabolic steroids serve a primary purpose, for example, they are primarily more efficient in bulking or in the dieting phase but most carry other traits suitable in a secondary nature for the other; there are very few anabolic steroids we would aptly label as pure bulkers or cutters. This is one of the things that make Trenbolone a little more special as it is equally efficient and effective for either type of cycle.
Trenbolone Acetate is a very powerful anabolic and androgenic steroidal hormone, so powerful it is 500 times more anabolic than testosterone as well as 500 times more androgenic; with this simple bit of knowledge we could stop right there and that would be enough to give you understanding of its true power. To understand the hormone a little more clearly we really only need to understand two things the Trenbolone hormone and how the Acetate ester affects it and by this understanding there will be no doubt, it is the most powerfully amazing steroid of all time.

Trenbolone exists by its structural alteration at the 19th position; simply meaning, the testosterone molecule has been altered at this point effectively making Trenbolone a 19-nor class anabolic steroid. By way of this alteration, like Testosterone, by its direct mode of action Trenbolone dramatically increases IGF-1 output but to a far greater degree than testosterone. As you understand IGF-1 is a very powerful anabolic hormone produced in all human beings and its role is so important it affects nearly every cell within the human body. In the case of Trenbolone, as it will cause massive amounts of IGF-1 to be released it will also firmly bind to the androgen receptors which in-turn greatly promotes both fat-loss and promotes growth. As you again understand most anabolic steroids have a positive impact on the metabolism and fat burning but in the case of Trenbolone this is one of the few anabolic steroids that burns fat in a direct manner, it actually directly enhances lipolysis. Tren, as it is more commonly known also plays a very important role the healing and regeneration process; this hormones ability to repair the cells is nearly ten times the amount of most anabolic steroids and as you understand it is the repairing and healing process that promotes enhancement in-terms of growth and strength as well as in the preservation of tissue when calories are restricted.

Of all the traits Trenbolone carries and we’re hardly done yet, there is one that may truly stand alone and it is what is known as “Nutrient Efficiency” or “Feed Efficiency.” As you know food is the most anabolic substance any of us will ever take in; in the world of performance enhancement nothing is more important than the food we eat, in general, when speaking of performance, “enhanced” or not food is the most important factor. So a question might be what if you could take the same food you’re eating and make it more valuable? Look at it like this, what if every dollar you had could purchase two dollars’ worth of any product you desire; wouldn’t you want to know how to do this? Well, we can’t speak on actual dollars and cents but we can speak on food. When Trenbolone is present in the body every gram of food you eat becomes more valuable, each nutrient enhances in value and is used in a more efficient manner by the body and closer to its full potential capacity.
 As you may be aware Trenbolone can come in several different forms, most commonly as Trenbolone Acetate but fairly commonly in the form of Trenbolone Enanthate as well. At one time what is now known as Tren-Hex was very popular, you may know it by its original name Parabolan but legitimate Parabolan is no longer manufactured. All Tren is the same in that it is all comprised of the same active Trenbolone hormone, however, the ester does play a few important roles but it does not change the direct nature of the hormone. As a small ester base anabolic steroid Trenbolone Acetate will become active very quickly in the body, a mere few days of use and there will be no question you’re using Tren. Attached to the Acetate ester, one of the smallest esters we will ever use Trenbolone Acetate has a half-life of approximately 3 days and this is very short, meaning every other day injections of the hormone are necessary and many will choose, although not completely necessary to inject the hormone on a daily basis. Further, as the Acetate ester is so small it takes up very little mass in the compound, meaning a larger portion of the compound will be Trenbolone than compared to other forms. This is true when we compare all large and small ester compounds but there is an interesting note regarding Tren. While we can adjust the dosing of any form to ensure we are getting the exact total amount of Tren we desire from any compound many individuals report not a only a stronger punch from the Acetate form but a smoother one as well.

Monday, August 11, 2014

What are the possible side-effects of oral steroids?

Oral steroids are used to treat a large number of conditions. Some examples include: inflammatory bowel diseases (for example, Crohn's disease, ulcerative colitis), autoimmune diseases (for example, autoimmune hepatitis), joint and muscle diseases (for example, rheumatoid arthritis, polymyalgia rheumatica), allergies and asthma. They are also used to treat some cancers. In addition they can be prescribed as replacement treatment for people who have stopped making their own steroids - Addison's disease.
Some general points about oral steroids.

    A short course of steroids usually causes no side-effects. For example, a 1-2 week course is often prescribed to ease a severe attack of asthma. This is usually taken without any problems.
    Side-effects are more likely to occur if you take a long course of steroids (more than 2-3 months), or if you take short courses repeatedly.
    The higher the dose, the greater the risk of side-effects. This is why the lowest possible dose which controls symptoms is aimed for if you need steroids long-term. Some diseases need a higher dose to control symptoms than others. Even for the same disease, the dose needed often varies from person to person.
    A common treatment plan is to start with a high dose to control symptoms. Often the dose is then slowly reduced to a lower daily dose that keeps symptoms away. The length of treatment can vary, depending on the disease. Sometimes the steroid treatment is gradually stopped if the condition improves. However, steroids are needed for life for some conditions, as symptoms return if the steroids are stopped.
For many diseases, the benefits of taking steroids usually outweigh the side-effects. However, side-effects can sometimes be troublesome. You should read the information leaflet that comes with your medicine packet for a full list of possible side-effects. The main possible side-effects include the following:

    Osteoporosis (thinning of the bones). However, there are some medicines that can help to protect against this if the risk is high. For example, you can take a medicine called a bisphosphonate to help prevent bone loss.
    Weight gain. You may also develop a puffiness around the face.
    Increased chance of infections, as steroids may suppress the immune system. In particular, you are at risk of having a severe form of chickenpox if you have not had chickenpox in the past (and so are not immune). Most people have had chickenpox as a child and are immune to it. If you are taking corticosteroids and have not had chickenpox in the past:
        Keep away from people with chickenpox or shingles.
        Tell a doctor if you come into contact with people with these conditions.
    Also, tuberculosis (TB) may flare up again if you had it in the past, even many years ago.
    Increase in blood pressure. So, have your blood pressure checked regularly. It can be treated if it becomes high.
    High blood sugar which may mean extra treatment if you have diabetes. Steroids may occasionally cause diabetes to develop. If you take long-term steroids, your doctor may arrange a yearly blood sugar test to check for diabetes - in particular, if you have a family history of diabetes.
    Skin problems such as poor healing after injuries, thinning skin, and easy bruising. Stretch marks sometimes develop.
    Muscle weakness.
    Mood and behavioral changes. Some people actually feel better in themselves when they take steroids. However, steroids may aggravate depression and other mental health problems, and may occasionally cause mental health problems. If this side-effect occurs it tends to happen within a few weeks of starting treatment and is more likely with higher doses. Some people even become confused, irritable and develop delusion and suicidal thoughts. These mental health effects can also occur when steroid treatment is being withdrawn. Seek medical advice if worrying mood or behavioral changes occur.
    An increased risk of developing cataracts.
    An increased risk of duodenal and stomach ulcers. Tell your doctor if you develop indigestion or abdominal (stomach) pains.

There is often a balance between the risk of side-effects against the symptoms and damage that may result from some diseases if they are not treated.

Tuesday, July 29, 2014

The Benefits of GP Winstrol

GP Winstrol is a very popular testosterone derived anabolic steroid from the Dihydrotestosterone (DHT) family that is available as an oral tablet or as an injectable in the form of Winstrol Depot. First developed by Sterling-Winthrop Laboratories in the early 1960’s the active hormone in the compound Stanozolol was given the trade name “Winstrol” and as is common in the anabolic steroid world the first trade name ever given has been the name most associate with the steroid. While many anabolic steroids are normally only found in certain circles some are found across the board in every athletic category imaginable GP Winstrol is such a steroid.  Winstrol is an ester free DHT steroid found in the form of a 17-Alpha-Alkylated steroid (17-aa) form as well as an injectable aqueous suspension (suspended in water.) Pertaining to the oral form the 17-aa alteration simply refers to the altered chemical structure that occurs at the 17th carbon position; without such restructuring the steroid would be useless in oral form. The 17-aa alteration allows the steroid to survive the first pass through the liver after ingestion and absorb into the blood stream where it becomes active, this has both positive and negative effects. The good news is once ingested it will enter the blood very rapidly, the bad news is it will bring about a level of toxicity to the liver as is common with most oral medications, steroidal and non-steroidal alike. 

As it pertains to the injectable aqueous form the same active Stanozolol hormone is being used, in that there is no difference. However, the toxicity to the liver will not be as large of a concern with the injectable form as by injecting the medication it goes to work directly and bypasses the first pass through the liver completely. Another important distinction is in the half-life, injectable GP Winstrol carries with it a half-life of approximately 24 hours while the oral Winny form as it is commonly known carries with it a half-life of approximately 9 hours. As you can see that’s a pretty big difference and administration will necessarily vary from one form to the next if absolute efficiency is going to be met.

As a DHT based steroid GP Winstrol is extraordinarily anabolic and only slightly androgenic, regardless of the form you choose this will hold true as will all other traits. As a powerful anabolic steroid GP Winstrol greatly enhances protein synthesis via its ability to dramatically increase nitrogen retention in the muscles all the while possessing no aromatase effects. Most all steroids can provide quality benefits to most any cycle for any purpose, however, most anabolic androgenic steroids generally have one primary purpose and secondary characteristics that may be apt for another cycle. For example, the powerful steroid Anadrol is used primarily as a bulking steroid as its nature is best suited for this purpose, however, it does possess traits that can be beneficial in a cutting cycle when used properly, this is very common in competitive bodybuilding circles. GP Winstrol however is a little different, while its primary purpose is without question a cutting cycle and in the aid in athletic performance there is not much use for this steroid in a bulking cycle as it is not by its mode of action designed to build large amounts of lean tissue. Even so, regarding cutting and athletic performance GP Winstrol is often a fine choice.

The primary benefit revolving around Winstrol are without question increases in strength and this can relate to physical power, speed and agility; further, as by its nature Winstrol can greatly enhance vascularity as well as promote a dryer and harder physique when body-fat is already low. While GP Winstrol will not specifically burn stored body-fat, most steroids won’t, it will have a very positive effect on this process. Winny is an excellent steroid for preservation purposes when in a caloric deficit as you should be if you are dieting and the more lean tissue we can hold onto when in this deficit the greater your metabolic rate will be, thereby leading to a leaner and harder physique.  Like all anabolic steroids Winstrol is not without the possibility of negative side-effects, however, the effects are often highly overstated and can largely be controlled by responsible use. Individual sensitivity will also play a role and the extent can vary from one person to the next as this is the case with all medications, steroidal and non-steroidal alike.

As discussed, liver toxicity is a concern, especially with the oral form as the oral form is a 17-aa steroid. Due to this fact we will necessarily limit the total time of Winstrol to 6-8 weeks at a time in order to protect the liver. However, while use will increase liver enzymes, in most all cases your liver will return to normal levels once use is discontinued and will never experience toxic levels anywhere near what daily alcohol consumption can bring and even regular use of many over the counter medications.

Friday, July 25, 2014

Benefits of Ipamorelin peptide

Like the GHRP-6 peptide (growth hormone releasing hexapeptide), it is a synthetic peptide that has powerful Growth Hormone releasing properties. And these GH releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.

Whereas GHRP-6 is a hexapeptide, Ipamorelin is a penta-peptide.The strength it displays may very well make regular old Growth Hormone (GH) obsolete. But what athletes and bodybuilders really want to know is what is this wonder peptide capable of doing, how is it used, and how does it compare to the other GHRP peptides? Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or three times daily, using a tiny insulin needle to inject. They usually start with the lower dose since side effects can include headaches or what feels like a head-rush. Ipamorelin can be taken at anytime but taking it about 30-45 minutes before a workout would seem ideal because of the pulse in Growth Hormone (GH) it creates allowing for maximum growth.

Studies on the effects of Ipamorelin on bone growth, body weight, and GH release showed some interesting conclusions.

In one experiment, various doses were administered over the course of 15 days to test the group's reactions.

There was a distinct and dose-dependent effect on body weight gain however, the treatment group did not show a change in total IGF-I levels. Nor did the treatment group produce serum markers of bone development. For example, the number of cells in the wide portion of the tibia (the shinbone) did not change significantly. This is a good thing because it suggests muscle growth with less potential for deformity of bone or cartilage.

The reaction of the pituitary to an aggressive i.v. dose of Ipamorelin showed that plasma GH levels were notably reduced whereas they were unchanged after a comparable dose of GHRH. This is actually a good thing as it suggests that Ipamorelin may not decrease your body's natural GH production - further demonstrating that Ipamorelin is a selective GH releaser.

GHRP-6Unlike GHRP-6, Ipamorelin does not induce hunger making it advantageous to those on a restricted calorie diet. And obviously, Ipamorelin's side-effects are enhanced when combined with anabolic steroids since they too influence Growth Hormone/Insulin Growth Factor release and production. In another study in rats, Ipamorelin released GH from rat pituitary cells as effectively as GHRP-6. Another document states that in healthy swine, Ipamorelin released GH with a consistency that is very comparable to GHRP-6. Also noteworthy was that none of the GH releasers tested affected FSH, LH, PRL or TSH blood serum plasma levels.

Ipamorelin in theory may increase Acetylchloine or Cortisol when used in higher dosages. However, and increase in Acetylchloine or Cortisol is even more likely with GHRP-2 and GHRP-6. In fact, in the case of Ipamorelin, there was little to no rise in Acetylcholine and Cortisol blood plasma levels even at injections more than 200 times higher than the effective dosage for comparable GH release.

This clearly proves that Ipamorelin is the first successful GHRP receptor agonist or chemical that binds to a receptor of a cell and triggers a response by that cell with a specific selectivity for the promotion of GH release by itself. Another advantage to Ipamorelin is that it doesn't cause sudden spikes in prolactin or cortisol as does GHRP-2 and GHRP-6. Ipamorelin is slower in its delivery unlike GHRP's which spike GH levels at a more rapid rate. The slower release is more natural and has a more sustained effect.

All in all it looks as if Ipamorelin is the new wave in GH releasing peptides. It appear to be more potent, longer lasting and potentially safer to use in the long run. More studies are being conducted all the time but as it stands, Ipamorelin looks like a serious contender in the arsenal of anabolic advancement.

Monday, July 14, 2014

Benefits of Femara (Letrozole)

Femara (Letrozole) is a type II (non-steroidal) third generation aromatase inhibitor. Clinically it is used to treat postmenopausal women with either estrogen receptor positive or estrogen receptor unknown breast cancer. In women, tumors that contain estrogen receptors are classified as estrogen receptor-positive (ER+) tumors. For Letrozole to be prescribed, a given tumor must have been diagnosed as estrogen receptor positive or estrogen receptor unknown. In the world of bodybuilding it is used to reduce or eliminate excess estrogen caused by the use of aromatizing steroids.

Letrozole was originally sold under the brand name Femara, and produced by the pharmaceutical house Novartis. It was patented on July 25th, 1997. Letrozole is known  as a type II aromatase inhibitor, meaning, in simplest terms that it attaches to the aromatase enzyme and prevents it from converting androgens to estrogen. In slightly more complex terms, estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme, and letrozole actually inhibits the production of estrogens in by competitive, (reversible) binding to the heme of the relevant cytochrome P450 unit. Letrozole is currently the most powerful aromatase inhibitor available. In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more. However, it’s use and benefits are not limited to eliminating estrogen in women.

In one male test subject Letrozole was able to reduce estrogen levels to undetectable levels, and in another clinical study done on both young and elderly men, intravenous administration of Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. Because estrogen is part of the negative feedback loop of the HPTA, Letrozole (and other anti-estrogens) are able to raise testosterone in male subjects. Letrozole was studied in men, and found to significantly increase LH levels to a 339 and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively. Letrozole was also able to produce a peak LH response to Gonadatropin Releasing Hormone equal to a 152 and 52% increase from baseline in either young or older men, respectively. In a similar study 0.02 mg of Letrozole increased testosterone by 45% after 2 days. That same twenty micrograms of Letrozole was also enough, in one study done on men, to reduce estrogen levels by roughly a third. Letrozole has a 2-4 day half-life, and it needs to be taken for up to 60 days to get a steady blood plasma level. Letrozole was used in a rodent study to effectively destroy (benign) breast tissue tumors, which may potentially indicate its use in males attempting to remove gynecomastia (aka gyno). As estrogen is also a factor in stopping linear bone growth, Letrozole is currently being examined for potential use in delay of growth seen in children.

In the world of bodybuilding where more is often thought to be better, Letrozole stands almost alone as an exception to that rule. Estrogen is necessary for healthy immune function, healthy cholesterol levels, joint health, cognitive function, and even aids in muscle growth. In my own experience as well as the experience of many bodybuilders and athletes I’ve worked with, Letrozole simply causes estrogen to be reduced to levels too low to function properly. Unfortunately, this compromised my immune system and joint integrity. For most recreational steroid users, Letrozole is going to be too harsh, and cause too many problems. Still, people can use it effectively if they don’t use the manufacturer’s clinical dose (2.5mgs) and instead keep their dose to .25-1mg. There are, however, better choices for an anti-estrogen. I should mention that using Letrozole at such a low dose does happen to make it a very good economic choice compared with other aromatase inhibitors.

For pre-contest bodybuilders, Letrozole is almost a necessity to eliminate water retention and achieve the ripped look necessary to compete in today’s bodybuilding world. However, in my experience, it is only necessary to be used for the last 4-6 weeks, to eliminate excess estrogen and water retention. After using Letrozole I recommend staying away from any estrogen suppression for at least a month to try to normalize the body.